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18:1-d7 lyso pe  (Avanti Polar)


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    Avanti Polar 18:1-d7 lyso pe
    18:1 D7 Lyso Pe, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 94/100, based on 32 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/18:1-d7 lyso pe/product/Avanti Polar
    Average 94 stars, based on 32 article reviews
    18:1-d7 lyso pe - by Bioz Stars, 2026-02
    94/100 stars

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    Albumin-associated lipids are consumed during cancer cell proliferation. A , comparison of lipid profiles across multiple lots of commercially available FBS (100% serum). B , lipid species detected in media with 10% FBS (Cytiva Lot #1), ranked by abundance. Lipids below the red line represent the bottom 1% of total lipid content. C , concentrations of individual lipid classes in media with 10% FBS used for subsequent experiments. D , fold change in concentration of the most abundant lipids, normalized to initial concentrations in media containing 10% FBS during cell proliferation. Each column represents individual lipid species over time, and the color indicates relative fold change: depleted ( blue ), no change ( red ), and increased ( white ). E , fold change in cell counts ( left ) and moving average of proliferation rate ( right ) in H1299 cells cultured in either 10% FBS or in serum-free DMEM supplemented with ITS and either LPC, LPE, or FA mix. F , average proliferation rate of cells over the entire assay. Error bars represent mean ± SD (n = 3). Statistical significance was assessed using Brown–Forsythe and Welch ANOVA tests ( F ). ns = not significant, ∗ p < 0.05. DMEM, Dulbecco's modified Eagle's medium; FA, fatty acid; FBS, fetal bovine serum; ITS, insulin–transferrin–selenium; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; PC, phosphatidylcholine; PE, phosphatidylethanolamine; SE, sterol ester; SM, sphingolipid; TAG, triacylglycerol.

    Journal: The Journal of Biological Chemistry

    Article Title: Defined media reveal the essential role of lipid scavenging in supporting cancer cell proliferation

    doi: 10.1016/j.jbc.2025.110693

    Figure Lengend Snippet: Albumin-associated lipids are consumed during cancer cell proliferation. A , comparison of lipid profiles across multiple lots of commercially available FBS (100% serum). B , lipid species detected in media with 10% FBS (Cytiva Lot #1), ranked by abundance. Lipids below the red line represent the bottom 1% of total lipid content. C , concentrations of individual lipid classes in media with 10% FBS used for subsequent experiments. D , fold change in concentration of the most abundant lipids, normalized to initial concentrations in media containing 10% FBS during cell proliferation. Each column represents individual lipid species over time, and the color indicates relative fold change: depleted ( blue ), no change ( red ), and increased ( white ). E , fold change in cell counts ( left ) and moving average of proliferation rate ( right ) in H1299 cells cultured in either 10% FBS or in serum-free DMEM supplemented with ITS and either LPC, LPE, or FA mix. F , average proliferation rate of cells over the entire assay. Error bars represent mean ± SD (n = 3). Statistical significance was assessed using Brown–Forsythe and Welch ANOVA tests ( F ). ns = not significant, ∗ p < 0.05. DMEM, Dulbecco's modified Eagle's medium; FA, fatty acid; FBS, fetal bovine serum; ITS, insulin–transferrin–selenium; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; PC, phosphatidylcholine; PE, phosphatidylethanolamine; SE, sterol ester; SM, sphingolipid; TAG, triacylglycerol.

    Article Snippet: LPE 18:1 (846725P), LPE 16:0 (856705P), LPC 18:1-d7 (791643), LPE 18:1-d7 (791644), and lipids used to generate calibration curves SPLASH LIPIDOMIX Mass Spec Standard (330707), LightSPLASH LIPIDOMIX Quantitative Mass Spectrometry (MS) Primary Standard (330732) were purchased from Avanti Polar Lipids.

    Techniques: Comparison, Concentration Assay, Cell Culture, Modification